Try to log in to webmail for any domain it returns 404 error

⌘K

This appiles to Plesk Windows version 7.5

This error means that web site webmail(default) responsible for webmail is misconfigured in IIS. To return it to working state you need to apply Plesk utility that will reconfigure webmail on the server.

"%plesk_bin%\defpackagemng.exe" --fix --type=webmail